4 Useful Small Cell Lung Cancer Tests

There are two main types of lung cancer; small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). SCLC is responsible for approximately 20% of these lung cancers. It is sometimes referred to as oat cell carcinoma due to the small cells in the lung bearing a similar resemblance to oats. This type of cancer develops when the small cells start to grow rapidly and uncontrollably. There are a number of signs that can indicate SCLC including a persistent cough, feeling out of breath for no apparent reason and chest pains. If you notice any of these signs or have any other reason to believe that you may have SCLC you should go see your doctor and get yourself tested. In this article I will be explaining some of the tests they may perform in greater detail.

1) PHYSICAL EXAMINATION:- The first test your doctor is likely to perform is a physical examination. This will allow them to ask you some questions about your overall health and to view your symptoms for themselves. They will also be able to question you about your smoking habits. Using this information your doctor can then determine whether you need further testing for SCLC.

2) CHEST X-RAY:- If your doctor feels that you require further testing following the physical examination they may recommend a chest x-ray. This will allow them to see if there are any visible abnormalities in the lungs which could turn out to be small cell lung cancer.

3) COMPUTERISED TOMOGRAPHY (CT) SCAN:- A CT scan is another useful small cell lung cancer test. It uses multiple x-rays to build a three dimensional picture of the lungs. Your doctor can then use this picture to get a better luck at any lumps or abnormalities that may have developed in the small cells.

4) BRONCHOSCOPY:- A bronchoscopy allows your doctor to look at the inside of your airways using a bronchoscope (a small, flexible tube which contains a camera or eyepiece). If they identify any possible tumours the bronchoscope can then be used to take a tissue sample. This sample can then be examined in a laboratory to determine whether small cell lung caner cells are present.

Although SCLC is one of the less common types of lung cancer it is still something that should not be ignored. If you develop a constant cough, chest pains or notice any other suspicious symptoms that affect your chest you should go see your doctor and talk to them about getting yourself tested. It may turn out to be nothing but it could crucially help you identify small cell lung cancer in the early stages when it is most treatable.

Whilst every intention has been made to make this article accurate and informative, it is intended for general information only. Small cell lung cancer is a very serious, life threatening condition and you should discuss any concerns, treatments or lifestyle changes fully with your doctor.

Silicon Wristband – The Spirit of Humanism Made Trendy and Fashionable

Most of us want to do something for the society in our small ways, but do not know exactly how to do this! The silicon wristbands in myriad designs and different hues offer you such a golden opportunity; it helps you to contribute to the society in a meaningful way without burning a hole in your pocket. After all, you are not a Bill Gates who can afford to donate a lion’s share of his fortune! Adorning your wrist with these trendy and affordable silicon bands, you will have this wonderful feeling that you are doing something meaningful for your fellow human beings. Apart from being an accessory for special cause, the silicon wristbands are one of the hottest tools for making fashion statement. They are also hugely used as promotional tools by a number of companies and other organizations.

Let’s take a flash back
Collecting wristbands has become a sort of fad these days. But there is an interesting story behind how all these began and that reflects the undying spirit of human struggle against destiny. The silicon wristbands of today are the legacy of the yellow rubber wristbands that incorporated premiere American cyclist Lance Armstrong’s fight against cancer. The yellow color in “LiveStrong” wristbands signified the yellow jersey that the courageous sportsman resolved to wear in the Tour de France cycling tournament despite being diagnosed with testicular cancer. This LiveStrong band was part of his gear when he emerged victorious in his last Tour De France. Since then, these yellow wristbands have come to signify courage and enormous will power to survive the killer disease of cancer.

Jump cut to present
You can not find a more popular accessory that is liked by the teenagers as well as the middle aged, male or female, celebrities or the commoners than a silicon wristband. The coolest thing about this accessory is that they allow you to demonstrate your support of a cause or organization, without requiring you to compromise on the fashion factor.

Wide selection
You will find silicon wristbands in variety of styles and designs. Even the children can wear them, as the bands are generally found in two sizes: child and adult. The young and old like them as fashion accessories simply because they complement all types of outfits. You will find different types of silicon wristbands to complement your cause as well as your sense of fashion:

– Slim Silicone Band
– Interlinked band
– Intertwined Band
– Debossed or embossed band
– USB Wristbands
– Glow in the Dark Wristbands

So you have found the easiest way of supporting a great cause; simply flaunt a fashionable silicon wristband and fight for a better society. A little piece of information for you in the end: these silicon bands are absolutely hygienic and they can be worn in wet as well as dry Environments.

Herbal Colon Cleansers – Do They Work?

Today, there are many reports of illness and poor health status because of poor eating habits. One of the health problems experienced by most people is colon cancer. This is brought about by poor eating habits that result to ineffective removal of waste matter from the body.

Herbal Colon Cleansers

There are different kinds of herbs in herbal colon cleansers that work together to eradicate toxins and waste that have built up in the body, especially in the digestive track. The herbal colon cleansers come in a different forms and brands. Herbal colon cleansers are good in improving health, increasing blood flow and improving the respiratory mechanism.

The benefits of taking herbal colon cleansers are many and among them are the following;

Promote Good Health

Herbal colon cleansers promote good health of the body due to their ability to remove toxic substances from the body. The reason why this is possible is that almost 8% of the food we take is not properly digested and as a result, it coats itself along the walls of the intestines or the colons. This leads to colon cancer, a disease that is common in people.

Fight Germs

Herbal colon cleansers have powerful substances that fight germs. In this way, the effectiveness of the immune system of the body is greatly increased thus leading to a strong body. The habit of taking fatty and sugary foods is causing many health problems such as constipation, abdominal pains and exhaustion. These are problems associated with an ineffective colon. When herbal colon cleansers are taken, all such toxins and waste matters are removed making the colon remain free of problems. You therefore experience increased energy, good blood flow and have a smooth skin.

Weight Loss

Herbal colon cleansers also assist in weight loss. Most of the herbs break down the excessive fatty acids in the body and remove all the dirt from the body leaving the body light and free. Absorptions of helpful nutrients into the body is also enhanced with the aid of natural herbs.

Cleans the Body

Some herbal elements, especially the natural ones, get rid of toxic substances in the body without the body feeling irritable and without harshness. A substance such as fiber is very essential in cleansing the body naturally. The effectiveness of the fiber is increased by flax seeds which remove pesticides and detoxify the body.

Little Side Effects

As far as clinical tests are concerned, herbal colon cleansers have little, if any side effects but numerous advantages. They revitalize the body’s energy and increase water flow out of the body by dissolving foods that aren’t able to be absorbed into the body. This increases blood circulation and purifies the inner system of the body. As such, there are no better alternatives to colon cleansers other than the natural herbal colon cleansers. Herbal colon cleansers have received wide acclaim from users due to their effectiveness and reliability.

Herbal cleansers can be taken with other foods or on their own depending on the choice of the person. Most herbal cleansers can be taken throughout even if there are no prescriptions.

Bladder Cancer – Strikes 61,000 Americans a year!

INTRODUCTION: Bladder cancer refers to any of several types of malignant growths of the urinary bladder. It characteristically causes blood in the urine; this may be visible to the naked eye (frank haematuria) or detectable only by using a microscope (microscopic hematuria).

It is the fourth most common cancer in men and the 9th most common cancer in women, affecting almost 61,000 Americans a year and is about four times more likely to be found in men than women. It is considered very common in the U.S.

TREATMENT: It depends on how deep the tumor invades into the bladder wall and is usually performed once a week for several weeks and can be repeated several times if the cancer returns. The most common treatment for superficial bladder cancer is BCG, a kind of biologic therapy which elevates the body’s immune system to fight the tumor. Medicines available include mitomycin-C, thiotepa, interferon and a newly available agent, valrubicin.

It has not yet been determined how the effectiveness of this form of treatment compares to that of radical ablative surgery. More than half of patients who opt for this treatment experience recurrence of the tumor (the cancer coming back).

TYPES: The most common kind begins in cells lining the inside of the bladder and is called urothelial cell or transitional cell carcinoma (UCC or TCC). World-class pathologists at Fox Chase Cancer Center examine tissues under a microscope to diagnose the type, as follows: Urothelial carcinoma or transitional cell carcinoma–accounting for 90 percent of bladder cancers as well as Squamous cell carcinoma, Adenocarcinoma and Small cell Related Cancers.

Surgeons at Fox Chase Cancer Center are highly capable in treating all types. Persons with cancer of the bladder sometimes have a similar kind of cancer in the lining of the kidneys (called the renal pelvis), the ureters or the urethra.

SYMPTOMS: While the symptoms of bladder cancer are few, they are noticeable. These signs and symptoms are not however specific to cancer of the bladder, and are also caused by non-cancerous conditions, including prostate infections and cystitis. Possible symptoms include pain during urination, frequent urination (Pollakiuria) or feeling the need to urinate without results.

Many patients with a history, signs and symptoms suspicious for the disease are referred to a urologist or other doctor trained in cystoscopy, a procedure in which a flexible tube carrying a camera and various instruments is introduced into the bladder via the urethra.

RISK: Approximately 20% of cases occur in patients without predisposing risk factors. It has been proposed that hair dyes are a risk factor. Hairdressers are thought to be at risk as well because of their frequent exposure to permanent hair dyes. Occupations at risk are metal industry workers, rubber industry workers, workers in the textile industry and people who work in printing. Some studies also suggest that auto mechanics have an elevated risk due to their frequent exposure to hydrocarbons and petroleum-based chemicals. A family history of the disease is also a risk factor.

Conclusion: Cancer of the bladder is a disease in which cancerous cells form in the tissues of the bladder. Such cases may be treated with surgery, radiation therapy, chemotherapy, biologic therapy or a combination of methods. Exposure to environmental carcinogens of various kinds is primarily responsible for the development of most bladder cancers.

The gold standard for diagnosing the disease is urine cytology and transurethral (through the urethra) cystoscopy. Cytology is very specific (a positive result is highly indicative of bladder cancer) but suffers from low sensitivity (a negative result does not exclude the diagnosis of cancer). 90% of cases are Transitional cell carcinomas (TCC) that arise from the inner lining of the bladder called the urothelium.

In the U.S., bladder cancer is the 4th most common type of cancer in men and the 9th most common cancer in women. Over 47,000 men and 16,000 women are diagnosed with the disease each year. There are now newer urine bound markers for the diagnosis of bladder cancer.

Cancer Biopsy Cases Pervade Medical Clinics

The term biopsy can be taken to mean a view of life and can be taken to mean from the Greek “bio” meaning life, and “-psy” meaning vision. A biopsy is literally a look at living tissue, and is a test used to detect cancer. Any tissue or organ in the body has the potential of being be biopsied, and there are several techniques used. Some of these engage surgery, whereas others will not even engage an anesthetic. In each method, a sample of tissue is extracted from the body and studied for cancer markers, cancer cells, or unusual cell division. Each cancer has its own methods of diagnosis, but the different types of biopsies can be classed. Naturally, you should go to a reputed medical clinic to get this done. You can look up an online health directory to find information.

1) Excisional biopsy. This is a surgical removal of the possible tumor growth. In this case, either an organ or lump is excised, or cut out of the body. Excisional biopsies are used for a variety of cancer diagnoses and for different reasons in each. In osteosarcoma they are used because of the growth rate of possible tumors. Surgery will always be the first preference of biopsy in bone cancers. In lymphoma, tumors can only be examined as whole pieces to obtain an accurate diagnosis. Breast cancer another cancer-type where ordinarily surgeons prefer surgery. This will make certain any cancer diagnosis with the most accuracy.

2) Incisional Biopsy. Here only a section of the lump is removed through surgery. This type is generally used for possible soft tissue cancers.

3) Endoscopic Biopsy. This is the most preferred form of biopsy and is performed through a fibreoptic endoscope that is placed inside the organ of disruption. The doctor looking through the endoscope can view directly any abnormal sections and cut or pinch pieces of tissue with forceps. A thoroscopy for endoscopic biopsy under general anesthesia will be used for mesothelioma, a cancer of internal organ lining. The reason for this is there is simply no other methods to obtain a tissue sample. Meshothelioma is also very tough to detect through other means, and so excisional biopsy is the best course for an accurate diagnosis.

4) Fine needle aspiration is the most preferred form of biopsy today. Here a needle will be placed inside the lump and a large number of cell tissue will be drawn through a syringe. These cells will then be stained and studied by a pathologist. In this case, a diagnosis is reached at once. This kind of biopsy can even be carried out on difficult to reach organs such as the pancreas or lungs with ultrasound guided techniques. This is the preferred choice as avoiding surgery is almost always first on the wish list of the cancer specialist.

There are other forms of biopsies, but these categories are the most preferred and cover most of the major cancerous diseases. If a cancer is possible, a patient may have to go through more than one of these tests through the course of their treatment, depending on how aggressive the cancer specialist feels it is.

Specialist medical clinics are most prepared to deal with this. If you want to learn more, read web pages on the issue. These are found easily in a health directory.

Experienced Gastrointestinal Specialists

Gastroenterology is a field of medicine that deals with the digestive system and the disorders related to it. The diseases that come under the study of gastroenterology are the diseases affecting the gastrointestinal tract. This tract includes the organs from mouth to anus including the alimentary canal. Thus a gastroenterologist is a certified specialist that diagnoses and treats the problem related to the digestive system and the digestive tract.

A experienced and certified gastroenterologist will be able to diagnose and treat the following problems,anorectal conditions, hemorrhoids,colonic,neoplasms,cancer,polyps,diverticulosis,esophageal reflux,gastritis,Gastroesophageal Reflux Disease (GRD),hepatitis,hiatal hernia,inflammatory bowel diseases,ulcerative colitis,crohn’s disease,irritable bowel syndrome,and ulcers. The city of Delhi is a renowned location for different medical institutions and related hospitals.

Many government and private sector hospitals are founded and established here. Every year thousands of patients from all round the country and world come to the region is search of better treatment. If you are looking for the Gastroenterologist in Delhi than you can go through different well known health portals that provide all the information related to the reliable medical facilities and experienced medical practitioner that provide reliable treatment. The top notch hospitals of the city have new age medical equipment and tools to treat different medical conditions and problems related to different patients.

The city has shown an impressive development on the medical sector since last few decades. The treatments provided by the hospitals are affordable and reliable. The skilled practitioners have years of experience in dealing with the problems related to the gastrointestinal diseases. A skilled gastroenterologist s able to diagnose the patient properly and is able to manage the different symptoms shown by different gastrointestinal patients like,abdominal pain,abnormal x-ray findings,constipation,diarrhea,difficulty in swallowing,heart burn,indigestion,jaundice,liver disease,malabsorption,nausea,post operative colon tests,rectal bleeding,unexplained weight loss,and vomiting.

These specialists will run some tests that are related to gastrointestinal problems like,colon screening exams,esophageal and intestinal dilation,hemostasis,and polypectomy. The patients with gastrointestinal problems can also look for the best gastroenterologist in Gurgaon. The city is a business class neighboring region of Delhi city and is home to many age old medical institutions and hospitals with excellent treatment facilities and provisions. Although in some cases the gastroenterologist do perform surgery but they mainly deal with the diagnosis and treatment of the problems related to the digestive system and the organs related.

Many top notch hospitals of the city have also maintained their online website that provides complete information related to the hospital and the types of medical facilities are provided to the patients and the different surgeons,doctors and other medical practitioners that will provide the needed treatment to the different patients,you can go through their official sites and can easily get the contact address and number for the further inquiry. The city of Ghaziabad is located in the Indian state of Uttar Pradesh and has been rapidly progressing in the past few decades. This industrial sector is also an important educational and medical center of the state where different medical institutions and hospitals are established and are successfully providing quality treatment to the patients coming from different parts of the country.

The gastroenterologist in Ghaziabad can be easily contacted for the proper consultation and treatment related to the gastrointestinal problems.

Skin and a host of other treatments with Himalaya Haridra

TriphaLax from Savesta: Natural remedies for constipation Savesta TriphaLax is an Ayurvedic remedy that can provide relief from occasional constipation and at the same time maintain proper digestion. But most importantly, it is known to be a gentle laxative. It helps relieve chronic constipation, regularize bowel movements and even treats assimilation.

Savesta TriphaLax contains Indian Senna which according to Ayurveda helps in decreasing the pita in the patient’s body and at the same time stimulates free movement of Vata in the body. Natural remedies for constipation such as Indian Sienna stimulate the liver for proper secretion of the enzymes. TriphaLax from Savesta also contains Triphala which is well-known Ayurvedic formulated and used in to rejuvenate as well as improve the digestive system. The coriander fruit is also included in TriphaLax which helps in to soothe as well as stimulate digestion.

TriphaLax from Savesta: Key ingredientsTriphala Senna Alexandrina Organic Coriander Sativum fruitsTriphaLax from Savesta: BenefitsIs a natural remedy that treats constipationHelps in maintaining proper digestionHas laxative propertiesStimulates the liver for proper secretion of enzymesIncreases bile acid secretion that assists digestionAlso has rejuvenative propertiesSince Triphalax from Savesta contains Senna. Thus, avoid using it totally if you have developed diarrhea, loose stool or abdominal pain since Senna might worsen the condition and thus can be harmful to your health. Consult your physician if you frequently have diarrhea or if you are pregnant, nursing, taking medication or even have a medical condition.

What is Turmeric/Haridra from Himalaya? Turmeric is the one of the most significant herb in Ayurveda Medicine which is known as ‘Haridra’ (Sanskrit name) – The Yellow in color, warm, rough, bitter in taste. Haridra is also known as Haldi and Gauri. The botanical name of Haridra is ‘Curcuma longa’. Haridra has wide medicinal uses. It is used to cure diseases like obesity, itching, pain in sinus, cough, asthma, skin disorders, leprosy, and allergic condition, discoloration of skin, anorexia, hemorrhoids, dyspepsia, hemoptysis, fever, and hysteria. This herb is a common cooking spice having numerous therapeutic effects. Haridra mainly found in India and Indonesia. This common medicinal herb is commonly used as spice in many recipes, to add color to recipe and also gain its medicinal benefits. Sprinkling of Turmeric powder on wound can prevent secondary infection and analgesic of scorpion bite. Haridra herb contains Vitamin A, Protein, Fatty acid, Mineral and carbohydrates. It is known to have antibiotic, anti-microbic and anti-inflammatory properties. Recent study of Haridra proves that it slows the spread of breast cancer into lungs and other body parts. Turmeric has a warm, bitter taste and is used extensively as a food flavoring. It is also used in spice in curry powder and mustard. It is being used in clinical trials for the treatment and prevention of pancreatic cancer. It is useful in treating and maintaining liver and gallbladder functions. Haridra prevents blood clots by anti-coagulation properties.

Benefits And Uses Of Ginger

Ginger is just as familiar in our kitchen as garlic and has a long reputation of being a medicinal plant. Even the biggest skeptic of plants aiding in healthy will reach for ginger ale at the sign of stomach upset!

Ginger’s scientific name is Zingiber officinale Roscoe, and the part we know is found underground, also called the rhizome of the plant. Ginger is also called root ginger.

Ginger has a long history for treating ailment and as a health aid. Both China and India viewed it as an advanced medicine applying it in different treatments for its toning abilities and spiritually uplifting properties and more recently, in the western world, it has been noted for its ability to bring about digestion, calm down stomach upset, and ease aches and pains.

There has been a great deal of research on ginger and its therapeutic effects, mostly in Japan and Europe while the western world seems to still be catching up.

Ginger improves digestion of proteins as well as being an effective treatment for sea sickness and motion sickness. Most over the counter pills you find for motion sickness will have ginger in them. It also strengthens the mucosal lining of the upper gastrointestinal tract that can protect from ulcers and intestinal parasites.

When you dry ginger you change the chemistry of it and it has different properties for healing. When you dry it you form shogaols which is a compound that has a more powerful anti-inflammatory and analgesic effect. People with arthritis and other inflammatory ailments may get much more benefit for dried ginger or powdered ginger than from fresh for those ailments. You can buy them in most health food stores.

If you want to steal a good trick for your cooking you should note that ginger is used widely in Chinese cooking as it cancels out the unwanted effects of other ingredients that can produce indigestion.

A great and popular way to take your ginger is in ginger tea. Put a half of teaspoon if freshly grated ginger into a cup of boiling water and steep for about ten minutes or so. Then strain the ginger out and add honey to taste. You can drink this hot or cold.

There is also honey based ginger syrups available for purchase that you can add to drinks or you can make it on your own by adding one par ginger to three parts raw honey and keep it in the refrigerator to stay fresh.

The side effect of ginger is possible heartburn if you take too big of an amount on an empty stomach. Funny that it heals the stomach but can cause heartburn! The best way to take fresh ginger is with food to avoid this from happening.

Benefits of Stem Cell Treatment and Stem cell Therapies

Numerous medical examiners and doctors believe that stem cell treatments have the power to revolutionize the face of human diseases and assuage suffering. Stem cells have the ability to regenerate more stem Cells and this makes it a valuable in field of medicine. It has the capability to generate tissues that can replace damaged cells in the body, with least risk of any side effects.

There are numerous stem cell therapies that are prevalent today, but most of them are at various stages of experiment and are exorbitant. Although one noteworthy success achieved through the stem cell treatment is the bone marrow transplantation. As per the recent study in medical science, researchers predict that cancer can be treated through the adult embryonic stem cells. The stem cell therapies can cure fatal diseases like diabetes mellitus, Heart Attack patients, and critical neurological disorders. It is also known for curing Parkinson’s disease and stages of Huntington’s disease. Treatment for muscle damage and numerous others.

As per cell therapeutics, despite the benefits of the stem cells therapies, it needs more research before transplantation of the damaged cells.

Currently this therapy is used to cure fatal stages of Cancer. This is done through the bone marrow of one’s own body or using the cells of one’s own umbilical cord blood stem cells. This is more applicable in the treatment of Blood Cancer that is caused due to abnormal increase of the white blood cells in the body. This therapy is also applied in cure of another type of Cancer called the Lymphoma Cancer; this is a type of Cell that is a part of the Immune system of the body.

With the advance research and study of the Stem cell in Medical Science, this therapy can be also used to cure serious diseases such as Brain damage, loss of hair, various types of cancer, injuries related to the spinal cord, cardiac related problems, vision impairment and deafness. Other issues those are common such as the missing tooth, healing of the wounds, diabetes. The most common problem that working g couple faces these days is infertility and orthopedics.

The application of this method of treatment is now understood due to its various benefits and ability to cure deadly disease. It empowers the human body to repair and recover from the damaged and injured cells through using the new cells that regenerate and refurbish within the body. It prevents shrinkage of cell and enriches the supply of blood and endorses tissue regeneration.

Today curing various stages of fatal diseases is made possible with the advancement in the research of application of stem cells. it has revolutionized the approach towards treating various cardiac related problems. However it has also led to rise of many doubts and concerns on the possibility of side effects, conditions of the patient to undergo this therapy, which genre of cells is used and in what quantity. How do these cells regenerate in the body? What is the age of these cells until which they are active in the body, does it also require perpetual replacement of the old cells with the new cells? What safety and precautions measures are taken while treating a patient is there any potential risk in the use of the stem cells?

Amylin's Share Pullback Is Unjustified.

In a 6-6 vote by the FDA Scientific Advisory Committe, it was determined that Liraglutide ( a diabetes drug made by Nono Nordisk) posed a significant risk in causing thyroid tumors in humans. While the panel was worried about animal studies showing that liraglutide caused medullary thryroid cancer in both mice and rats, Novo Nordisk denied any evidence of the drug causing such a cancer in humans.

Moreover, some members of the panel were worried that any thyroid risk might apply to the whole class of drugs: GLP -1 class. However, there is currently no clinical evidence that thyroid cancer is a GLP-1 class effect. Amylin pharmaceuticals who is conducting clinical trials on the safety and efficacy of another diabetes agent, Byetta (GLP -1 drug), found no thyroid C-cell carcinoma association. Amylin executives stated that they haven’t seen any risks of cancerous tumors with Byetta, and only minimal evidence with the long-acting version, exenatide LAR, which will be submitted for FDA approval in coming months.

No cases of thyroid cancer have been documented in patients enrolled in clinical trials of Byetta, according to Amylin Pharmaceuticals. Amylin conducted a two-year cancer study of long-acting Byetta in rats and mice and found a statistically significant increase in tumors only in female rates treated with doses of long-acting Byetta four-fold higher than what would be given to humans. By comparison, Novo Nordisk’s liraglutide was found to cause tumors in male and female rats, sometimes at human-equivalent doses.

last week, Amylin released positive results from DURATION-2 that demonstrated superiority of Byetta once weekly as compared to two commonly prescribed diabetes medications, Januvia(TM) (sitagliptin) and Actos (pioglitazone). Also, a meta-analysis of primary cardiovascular events across controlled clinical studies of three months or greater, from the BYETTA (exenatide) injection database, showed no increased risk of cardiovascular events associated with the use of exenatide.

Since Byetta and liraglutide are distinct molecules, how is it scientifically sound to assume that what is seen with one molecule will automatically be seen with the other? Clearly , the FDA’s concern regarding the threat of thyroid cancer in Amylin’s Byetta is rediculous! As a matter of fact, FDA officials publicly pointed out, last week, that they did not see any risk of thyroid cancer with Byetta after re-examining data on the four-year-old drug. Additionally, animal testing of Byetta did not uncover the same level of a thyroidtumor risk as Novo Nordisk’s Liraglutide.

Though both liraglutide and Byetta belong to the sames class of drugs called GLP-1s, the latter may deliver a cleaner preclinical safety profile than liraglutide. However, there is one shortcoming in Byetta’s clinical trial. Scientists wonder if less than 500 patients from Byetta’s LAR’s DURATION-1-3 trials are sufficient to address the FDA’s concern over a potential ‘class effect’ for thyroid cancer that could increase with longer-acting agents, and if additional trials would be required. I think not.

According to President and Chief Executive Officer Daniel M. Bradbury and his management team, exenatide once weekly is on track for a planned launch in 2010. The steps that the company has taken to enhance the commercial opportunities of the product are already beginning to yield results. With data supporting efficacy, safety and manufacturing now in hand, Amylin anticipates filing a new drug application (NDA) for exenatide once weekly by the end of this quarter.

Disclaimer: The author does own securities in relation to Amylin Pharmaceuticals. Certain matters discussed in this article may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and the Federal Securities Laws. Such statements are subject to certain risks, trends, and uncertainties that could cause actual results to differ materially from those projected. For that matter, the author assumes no obligation to update or supplement any forward-looking statements whether as a result of new information, future events or otherwise.